(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid
(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid
CAS: 281655-37-6
Molecular Formula: C20H19NO5
(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Names and Identifiers
| Name | (3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid |
| Synonyms | FMOC-S-MO3C-OH FMOC-S-MORPH-OH N-FMOC-MORPOLINE[(3S)-COOH] (S)-FMOC-3-CARBOXYMORPHOLINE (S)-Fmoc-2-Carboxymorpholine (S)-FMOC-2-CARBOXYMORPHOLINE (S)-4-Fmoc-3-morpholinecarboxylicacid (S)-N-(9-FLUORENYLMETHYLOXYCARBONYL)-MORPHOLINE-3-CARBOXYLIC ACID (3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid (S)-4-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)MORPHOLINE-3-CARBOXYLIC ACID |
| CAS | 281655-37-6 |
| InChI | InChI=1/C20H19NO5/c22-19(23)18-12-25-10-9-21(18)20(24)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17-18H,9-12H2,(H,22,23)/t18-/m0/s1 |
(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C20H19NO5 |
| Molar Mass | 353.37 |
| Density | 1.344 |
| Melting Point | 128-130℃ |
| Boling Point | 579.8±50.0 °C(Predicted) |
| Flash Point | 304.4°C |
| Solubility | Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.77E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.47±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.621 |
(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Risk and Safety
| HS Code | 29334900 |
(3S)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid - Introduction
(3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is an organic compound with the chemical formula of C₂ H₂ NO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White to yellowish solid
-melting point: about 124-125 ℃
-Solubility: Soluble in some organic solvents such as methylene chloride, dimethyl sulfoxide and ethanol
Use:
- (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a commonly used organic synthesis intermediate.
-It is usually used in the fields of drug synthesis, protein chemistry and peptide synthesis.
-It plays an important role in the synthesis of chiral compounds, pharmaceutical research and synthetic biology.
Method:
The preparation method of (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is as follows:
1. Reaction of (S)-4-hydroxy-3-morpholinecarboxylic acid with 9-fluoroprimary amine fluorene carboxaldehyde to give (S)-4-[(9h-fluoren-9-yl) methoxy] morpholine-3-carboxylic acid.
2. The above product was reacted with diethyl tetrafluoroborate in the presence of sodium chloride to obtain (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid.
Safety Information:
- (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is relatively stable at room temperature, but it needs to be stored away from light.
-Wear appropriate protective gloves and eye protection when handling this compound.
-Avoid inhalation, ingestion or contact with skin.
-If you come into contact with this compound, wash it immediately with plenty of water and seek medical attention if necessary.
Nature:
-Appearance: White to yellowish solid
-melting point: about 124-125 ℃
-Solubility: Soluble in some organic solvents such as methylene chloride, dimethyl sulfoxide and ethanol
Use:
- (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is a commonly used organic synthesis intermediate.
-It is usually used in the fields of drug synthesis, protein chemistry and peptide synthesis.
-It plays an important role in the synthesis of chiral compounds, pharmaceutical research and synthetic biology.
Method:
The preparation method of (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is as follows:
1. Reaction of (S)-4-hydroxy-3-morpholinecarboxylic acid with 9-fluoroprimary amine fluorene carboxaldehyde to give (S)-4-[(9h-fluoren-9-yl) methoxy] morpholine-3-carboxylic acid.
2. The above product was reacted with diethyl tetrafluoroborate in the presence of sodium chloride to obtain (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid.
Safety Information:
- (3s)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-3-carboxylic acid is relatively stable at room temperature, but it needs to be stored away from light.
-Wear appropriate protective gloves and eye protection when handling this compound.
-Avoid inhalation, ingestion or contact with skin.
-If you come into contact with this compound, wash it immediately with plenty of water and seek medical attention if necessary.
Last Update：2024-04-09 02:00:44
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CAS: 281655-37-6
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Tel: 18301782025
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